The polypill in the prevention of cardiovascular diseases: key concepts, current status, challenges, and future directions.

摘要

Cardiovascular disease (CVD) is the major cause of death and disability globally1 and affects approximately half of all individuals over their lifetimes. The CVD burden has decreased in developed countries as effective prevention and treatment strategies were implemented, although these gains are threatened by increasing obesity, sedentary lifestyles, and diabetes mellitus. By contrast, CVD has increased in developing countries, and by the year 2020, 80% of the global CVD mortality is predicted to occur in low- and middle-income countries.