Metals in medicine: metal-related diseases-Highly active antitumor titanium(IV) phenolato complexes: the influence of structural factors on complex performance

摘要

The anticancer activity of the inorganic compound cisplatin and its worldwide use in the pharmaceutical industry initiated a new field of research, aimed at finding new inorganic complexes of other metals that may lead to improved anticancer drugs. Among others, Ti(IV) complexes titanocene dichloride and budotitane demonstrated high cytotoxic activity but eventually failed clinical trials due to their low hydrolytic stability. We previously introduced cytotoxic Ti(IV) complexes based on salan ligands that demonstrated high activity along with exceptional hydrolytic stability.