Metals in medicine: metal-related diseases-Synthesis and kinetic of metalation of 2,3,7,8,12,13,17,18-octakis(propyl), N,N,N',N'- tetramethylamino porphyrazines and 2,3,9,10,16,17,23,24-octa substituted phthalocyanine

摘要

Tetrapyrrole macrocyclic compounds such as phthalocyanine and porphyrazines and their metal complexes have found usage in medicine as potential photosensitisers for photo dynamic therapy in the treatment of cancer and tumour cells, as well as biomedical imaging agent [1]. Tuning of their properties may be achieved by the modification of their peripheral substituents and the incorporation of varied metal ions in their central cavity [1]. Peripheral functionalities may be symmetrical or unsymmetrical. Unsymmetrical substituents include the porphyrazine-phthalocyanine hybrid which combines the electronic character and extended p electron system of porphyrazines and phthalocyanines [2].