Bioinspired and biomimetic systems-Evaluation of the antioxidant, antihypertensive and antitumor activity of a Cu(II) and Irbesartan (Irb) complex [Cu(Irb)_2(H_2O)] (CuIrb): synthesis, characterization and DFT study

摘要

Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension [1]. Based on the fact that in some cases metal complexes displayed improved therapeutic properties compared to the parent drugs [2], we have synthesized a solid coordination Cu(II) complex with Irb and CuCl2 in ethanolic solution.