Paniculacin, a new coumarin derivative from Murraya paniculata

摘要

Paniculacin (1), a new coumarin derivative, has been isolated from the ethyl acetate soluble fraction of the ethanolic extract of Murraya paniculata along with umbelliferone, scopoletin, 4-hydroxybenzoic acid, trans-cinnamic acid, and beta-sitosterol. Their structures were elucidated on the basis of spectral data. The genus Murraya (Rutaceae) comprises 12 species that are distributed in tropical and subtropical regions of Southeast Asia, Mediterranean countries, N. America, Australia, and S. Africa. In Pakistan, this genus is represented by two species, one of which is Murraya paniculata. It is an evergreen shrub growing commonly in Sindh and Punjab provinces of Pakistan [1]. It is used by the local people to treat different ailments including diarrhea, chronic dysentery, gastralgia, toothache, skin irritation, swelling, bruises, and as a stimulant for menstrual flow [2].