East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina Possible Roles of Reactive Aldehydes and Implications of Alcohol Flushing Syndrome

摘要

Background-Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese.