SYNTHESIS AND HYDROLYSIS STUDY OF POLYACRYLATES CONTAINING 2',5-DICHLORO-4'-NITROSALICYLANILIDE

摘要

Monomers (meth)acryloyloxy-2',5-dichloro-4'-nitrosalicylanilide have been synthesized by treating 2',5-dichloro-4'-nitrosalicylanilide (niclosamide) with acryloyl or methacryloyl chloride, and polymerized by free radical polymerization to give a polymer containing chemically bonded niclosamide. The structure of monomer and polymer were confirmed by IR, UV, and elemental analysis. Hydrolysis data of polymer in different media indicated that the hydrolysis rates of polymer were strongly dependent on the nature of the polymer structure and the hydrolyzing medium. (C) 1997 John Wiley & Sons, Inc. [References: 12]