Surface Tailoring of Biomedical Polymers: An FTIR Study

摘要

A multistep, surface-tailoring process of polymeric materials was developed with two consecutive plasma treatments and followed by derivatization reactions. In the first step, tetrafluoroethylene was plasma-polymerized, generating a highly crosslinked perfluoric surface layer. The next step introduced amine groups into the plasm.a polymer through exposure of the surface to plasma of ammonia. The reactive amine moieties were then used as anchoring sites for further derivatization. Finally,poly(ethylene glycol) chains were grafted onto the surface via a hexamethylene diiso.cyanate spacer. This method, aimed at the chemical modification of polymers for biomedical applications, was first demonstrated with poly(ethylene terephthalate)(PET) as a substrate in a previously published study (Cohn, D.; Stern, T. Macromole-cules 2000, 33, 137). The aim of this study was to demonstrate the applicallility of the " method described previously to different polymers: poly(1actic acid), poly(ethylene) , (PE), polystyrene (PST), poly(methyl methacrylate), a pol,ybutadiene-based polyure- . thane (PEUOXAB-20), and Lycra. Fourier transform infrared (FTIR) spectroscopy was , used to characterize the surface-modified substrates and the various control treat- ments. The results obtained were I:onsistent with the derivatization scheme and in full agreement with the FTIR and ESCA results previously obtained for PET.