Obstructive sleep apnea: wreaking havoc with homeostasis.

摘要

the phenotypic characterization of obstructive sleep apnea (OSA) continues to unfold. Recent studies provide evidence that this syndrome has the potential to disturb cardiovascular, neurological, and endocrine homeostatic processes (1, 6, 8, 9). Li et al. (5) present convincing evidence that long-term exposure to hypoxia-reoxygenation, modeling oxygenation patterns of severe sleep apnea, impairs lipid homeostasis in the liver in an animal model of obesity and insulin resistance. This impairment suggests that hypoxia-reoxygenation patterns of sleep apnea could worsen nonalcoholic fatty liver disease.