Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure)

Greene Stephen J.; Hernandez Adrian F.; Sun Jie-Lena; Metra Marco; Butler Javed; Ambrosy Andrew P.; Ezekowitz Justin A.; Starling Randall C.; Teerlink John R.; Schulte Phillip J.; Voors Adriaan A.; Armstrong Paul W.; OConnor Christopher M.; Mentz Robert J.

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Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure)

机译：临床试验部位登记对患者特征，方案完成和终点的影响：ASCEND-HF试验的启示（奈西立肽治疗失代偿性心力衰竭的临床有效性的急性研究）

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Background Most international acute heart failure trials have failed to show benefit with respect to key end points. The impact of site enrollment and protocol execution on trial performance is unclear.

机译：背景技术大多数国际急性心力衰竭试验未能在关键终点方面显示出益处。尚不清楚站点注册和协议执行对试验性能的影响。

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《Circulation. Heart failure》 |2016年第9期|共10页
作者
Greene Stephen J.; Hernandez Adrian F.; Sun Jie-Lena; Metra Marco; Butler Javed; Ambrosy Andrew P.; Ezekowitz Justin A.; Starling Randall C.; Teerlink John R.; Schulte Phillip J.; Voors Adriaan A.; Armstrong Paul W.; OConnor Christopher M.; Mentz Robert J.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
clinical trial; heart failure; patient discharge; quality of life;

机译：临床试验;心力衰竭;出院;生活质量;

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1. Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) [J] . Greene Stephen J., Hernandez Adrian F., Sun Jie-Lena, Circulation. Heart failure . 2016,第9期

机译：临床试验部位登记对患者特征，方案完成和终点的影响：ASCEND-HF试验的启示（奈西立肽治疗失代偿性心力衰竭的临床有效性的急性研究）
2. Effects of nesiritide and predictors of urine output in acute decompensated heart failure: Results from ASCEND-HF (acute study of clinical effectiveness of nesiritide and decompensated heart failure) [J] . Gottlieb, S.S., Stebbins, Journal of the American College of Cardiology . 2013,第13期

机译：Nesiritide和尿量输出预测因子在急性失代偿性心力衰竭中的影响：Ascend-HF的结果（Nesiritide临床疗效和失代偿性心力衰竭的急性研究）
3. Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) [J] . Kelly Jacob P., Mentz Robert J., Hasselblad Vic, The American heart journal . 2015,第2期

机译：急性心力衰竭住院期间恶化的心力衰竭：奈西立肽在代偿性心力衰竭临床有效性的急性研究中的见解（ASCEND-HF）
4. Clinical trial of local anesthetic protocols for acute pain associated with caustic paste disbudding in dairy calves [C] . Annual Conference of the American Association of Bovine Practitioners . 2017

机译：乳制牛犊苛性粘膏中急性疼痛局部麻醉方案的临床试验
5. The development of an educational pre- and post-prescribing protocol for the use of nesiritide in acute decompensated heart failure through evidence -based medicine [D] . Kirkhart, Vincent R. 2006

机译：通过循证医学开发奈斯利肽在急性失代偿性心力衰竭中的处方前和处方后教育方案的开发
6. Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial [O] . Seraj Abualnaja, Mohua Podder, Adrian F Hernandez, 2015

机译：急性心力衰竭和心房颤动：奈西立肽在代偿性心力衰竭临床疗效的急性研究中的见解（ASCEND-HF）试验
7. Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) [O] . Greene, Stephen J., Hernandez, Adrian F., Sun, Jie-Lena, 2016

机译：临床试验部位登记对患者特征，方案完成和终点的影响：ASCEND-HF试验的启示（奈西立肽治疗失代偿性心力衰竭的临床有效性的急性研究）

Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure)

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