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首页> 外文期刊>Journal of Analytical Toxicology >Identification and quantification of cocaine N-oxide: a thermally labile metabolite of cocaine.
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Identification and quantification of cocaine N-oxide: a thermally labile metabolite of cocaine.

机译:可卡因N-氧化物的鉴定和定量:可卡因的热不稳定代谢产物。

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摘要

In this article, we report the identification and quantitation of cocaine N-oxide (CNO), a thermally labile oxidative metabolite, from both animal and human samples. The concentration of CNO is similar to the concentrations of cocaine in the samples analyzed. The technique used for the determination of CNO in this study is liquid chromatography-electrospray ionization mass spectrometry, which is necessary because CNO is converted to cocaine upon heating. This includes simple heating of aqueous solutions to temperatures in excess of 100 degrees C and analysis by gas chromatography-mass spectrometry (GC-MS), in which CNO is converted to cocaine in the injection port. The thermal conversion of CNO to cocaine is estimated to cause an over-reporting of cocaine levels by 10-20% when using GC-MS.
机译:在本文中,我们报告了动物和人类样品中可卡因N-氧化物(CNO)(一种热不稳定的氧化代谢物)的鉴定和定量。 CNO的浓度类似于分析样品中可卡因的浓度。本研究中用于测定CNO的技术是液相色谱-电喷雾电离质谱法,这是必需的,因为加热时CNO会转化为可卡因。这包括将水溶液简单加热到超过100摄氏度的温度,以及通过气相色谱-质谱(GC-MS)分析,其中CNO在进样口被转化为可卡因。据估计,使用GC-MS时,将CNO热转化为可卡因会导致可卡因水平过度报告10-20%。

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