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首页> 外文期刊>Journal of Analytical Toxicology >Occupational cocaine exposure of crime laboratory personnel preparing training aids for a military working dog program.
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Occupational cocaine exposure of crime laboratory personnel preparing training aids for a military working dog program.

机译:犯罪实验室工作人员的职业可卡因暴露为军事工作犬计划准备了助教。

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摘要

The potential for passive cocaine exposure was evaluated in crime laboratory employees preparing training aids for a military working dog program (MWD). The primary goal of the study was to elucidate the routes of exposure and implement procedural changes that would minimize this risk. Several work environments and laboratory procedures were examined by monitoring personal breathing zones (PBZ), ambient airborne cocaine levels in the laboratory spaces, and urinary levels of the primary cocaine metabolite, benzoylecgonine. The study was performed initially using current laboratory procedures to establish a baseline and to identify potential sources of exposure. A subsequent study was performed to determine the effectiveness of the follow-up procedure in reducing exposure. As a result of the changes, the 8-h time weighted averages (TWAs) were 40 to 80% lower in the follow-up study as compared to the baseline assessment. Dermal absorption and PBZ inhalation of cocaine during manufacture were likely the most significant source of cocaine exposure. Ambient airborne cocaine may have also contributed to the total exposure, but for most observations, the concentrations were significantly less than those determined from PBZ monitoring. The maximum ambient cocaine concentration was 0.0144 mg/m(3) compared to a maximum of 0.4004 mg/m(3) observed during PBZ monitoring. Occupational exposure decreased in the follow-up study because of the proper use of personal protective equipment and improvements in engineering controls.
机译:在犯罪实验室工作人员中评估了被动可卡因暴露的可能性,这些工作人员为军事工作犬计划(MWD)准备了训练辅助工具。该研究的主要目的是阐明暴露途径,并进行程序改变以最大程度地降低这种风险。通过监测个人呼吸区(PBZ),实验室空间中空气中可卡因的水平以及主要可卡因代谢物苯甲酰芽子碱的尿液水平,检查了几种工作环境和实验室程序。最初使用当前的实验室程序进行研究,以建立基线并确定潜在的暴露源。随后进行了一项研究,以确定后续程序减少接触的有效性。由于这些变化,在后续研究中,与基线评估相比,8小时时间加权平均值(TWA)降低了40%至80%。制造期间可卡因的皮肤吸收和PBZ吸入可能是可卡因暴露的最重要来源。空气中的可卡因可能也影响了总暴露量,但对于大多数观察而言,其浓度明显低于通过PBZ监测确定的浓度。最大可卡因浓度为0.0144 mg / m(3),而在PBZ监测期间观察到的最大可卡因浓度为0.4004 mg / m(3)。在后续研究中,由于适当使用了个人防护设备并改善了工程控制,职业接触有所减少。

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