Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols

摘要

The electrostatic charge properties of commercial metered dose inhaler(MDI)aerosols,including Ventolin~R,Flixotide~R,Tilade~R and QVAR~R,sampled through new and detergent-coated AeroChamber~R Plus spacers were studied using a modified 13-stage electrical low pressure impactor(ELPI)with aerodynamic cutoff diameters ranging from 0.028 to 10.07 mu m.Aerosol particles deposited on the impactor stages according to their aerodynamic diameters and their charges were simultaneously measured by the electrometers.The deposited drug mass was assayed chemically using HPLC.The surface potential on the inner spacer wall was measured with an electrostatic probe before and after aerosol actuation.High surface potentials were found on the new spacers whereas the detergent-coated spacers had minimal charges due to the conductive coating.MDI aerosol charges were decreased when spacers were used but the charge profiles of the aerosols were not altered qualitatively.New spacers had the lowest throat deposition,fine particle dose,and net aerosol and fine particle charges as a result of high spacer retention.These trends were partially reversed by the detergent-coated spacers.In general,the charge per mass of drug(charge-to-mass ratio)for particles from detergent-coated spacers was higher than those from new spacers.This was thought to be due to the reduction of electrostatic deposition inside the spacer thus leading to particles carrying higher charges being sampled.The calculated number of elementary charges per drug particle ranged from zero to several hundred,which is sufficiently high to potentially affect lung deposition.The ELPI provided high resolution charge profiles on MDI aerosols delivered through spacers.