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首页> 外文期刊>JAMA pediatrics >The tale of 2 trials: Disentangling contradictory evidence on hypertonic saline for acute bronchiolitis
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The tale of 2 trials: Disentangling contradictory evidence on hypertonic saline for acute bronchiolitis

机译:2个试验的故事:高渗盐水治疗急性毛细支气管炎的矛盾证据

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摘要

For pediatricians looking for answers on how best to provide treatment for their patients, nothing can be more frustrating than 2 randomized clinical trials (RCTs) with contradictory results. It may encourage nihilism and a throwing up of one's hands, thinking clinical researchers have no idea what they are doing by producing data and gaining publications but not shedding light on the tough management issues that pediatricians face day to day. These 2 RCTs on the use of nebulized hypertonic saline for the management of bronchiolitis could potentially lead practitioners to despair in this way. One RCT indicates that hypertonic saline is very helpful, can improve a patient's condition clinically, and can lead to reduced hospitalizations. The other RCT comes to the opposite conclusion. Yet ultimately, pediatricians need some guidance as to what to do with the next patient with bronchiolitis whom they will assess and provide with treatment.
机译:对于寻求有关如何为患者提供最佳治疗的答案的儿科医生来说,没有什么比两个具有相反结果的随机临床试验(RCT)更令人沮丧的了。它可能会鼓励虚无主义和举手投掷,认为临床研究人员不知道通过产生数据和获得出版物来做什么,但没有阐明儿科医生日常面临的棘手管理问题。这两项关于使用雾化高渗盐水治疗毛细支气管炎的随机对照试验可能会导致从业者以这种方式感到绝望。一项RCT表明,高渗盐水非常有帮助,可以改善患者的临床状况,并可以减少住院。另一个RCT得出相反的结论。但最终,儿科医生需要对将要评估并提供治疗的下一个毛细支气管炎患者的治疗方法提供一些指导。

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