A 3D modelling of the protrusion and retraction of a single cell during the motiliy and the rolling

摘要

The rolling is an important kind of cell adhesion, especially in the case of the immune mechanism, due to the leukocyte action, which is strongly influenced by molecular affinity [1]. Our purpose, in this paper, is the presentation of a 3D theorical model which describes the behaviour of the contact interface cell-wall during the rolling and the cell deformation. The first point concerns the modelling of the contact interface, which is assimilated to a circular plate, linked to the wall (e.g vein) by elastic springs. The second point concerns the modelling of the active deformation due to the change of the cytoskeleton structure during the cell motility.