Rapid synthesis of some new propanol derivatives analogous to fluconazole under microwave irradiation in solventless system

摘要

Fluconazole and a series of 2-(2,4-difluorophenyl)-1-(1H-1,2,4 triazol-1-yl- methyl)-3-(substituted heterocycl)-propan-2-ol which are analogous to fluconazole,were synthesized via the reaction of 2(2,4-difluorophenyl)-2-[1-(1,2,4-triazolmethide)]oxiran with various heterocyclic system under microwave irradiation in solventless system.