DEHYDROGENATIVE N-HETEROCYCLIZATION OF 2-(2-AMINOARYL)ETHYL ALCOHOLS TO INDOLE DERIVATIVES CATALYZED BY (μ-OXO)TETRARUTHENIUM CLUSTER/ l,2-BIS(DIPHENYLPHOSPHINO)BENZENE

摘要

A novel catalyst system of (μ-oxo)tetraruthenium cluster (2) combined with l,2-bis(diphenylphosphino)benzene (dppbz) realized a simple, selective, and practical synthesis of indole and its derivatives from 2-(2-aminoaryl)ethyl alcohols via dehydrogenative N-heterocyclization reaction. Spontaneous formation of a stoichiometric amount of hydrogen (H2) was observed, and the present reaction proceeded smoothly under an argon atmosphere without oxidants and/or hydrogen acceptors.