Javaberine A new TNF-#alpha# and Nitric Oxide Production Inhibitor, from the roots of Talinum Paniculatum

摘要

The methanolic (MeOH) extract from the roots of Talinum paniculatum was found to exhibit inhibitory activities on the lipopolyosaccharide (LPS)-induced tumor necrosis factor (TNF)-#alpha# and nitric oxide (NO) production from mouse peritoneal maacrophages, and on the TNF-#alpha# production from rat eopididymal alipose tissue. From the MeOH extract, two new 8-benzyltetrahydro-protoberberine-type alkaloids, named javaberines A and B, were isoalted and their structures were elucidated on the basis of chemical and physicochemical evidence. The principal alkaloid, javaberine A, inhibited LPS-induced TNF-#alpha# and NO production from mouse peritoneal macrophages and TNF-#alpha# production from rat epididymal adipose tissue.