SYNTHESIS OF OPTICALLY ACTIVE P-CHIROGENIC FERROCENE FUSED BENZOPHOSPHOLE BY DISTEREOSELECTIVE INTRAMOLECULAR CYCLIZATION OF PHOSPHANYLFERROCENE DERIVATIVES

摘要

A novel optically active P-chirogenic ferrocene-fused benzo-phosphole, (S_(Fc),R_p)-4-phenylbenzo[b]ferroceno[d]phosphole, was synthesized by diastereoselective intramolecular cyclization of (s_(Fc))-1-(diphenylphosphanyl)-2-(2-lithiophenyl)ferrocene intermediates in two routes. The geometry of the new P-chirogenic ferrocenophosphole including absolute configuration of the phosphorous was disclosed by single crystal X-ray analysis of the palladium complex derived from the reaction of the phosphole with di-μ-dichloro-bis {2-[(dimethylamino)methyl]phenyl-C~1,N}dipalladium(II).