WATER-TOLERANT AND REUSABLE CATALYST FOR THE ONE-POT SYNTHESIS OF DIHYDROPYRIMIDIN-2(1H)-ONES UNDER SOLVENT-FREE CONDITIONS

摘要

An efficient and eco-friendly synthesis of 3,4-dihydropyrimidin-2(1H)-ones,has been achieved by a three-component condensation reaction of an aldehyde,beta-ketoester and urea,in the presence of K_5CoW_(12)O_(40) centre dot 3H_2O (0.01 equiv.or 1.0 mol %) as catalyst under solvent-free conditions.The catalyst exhibited remarkable reusable activity.The scope of this method is utilized for the synthesis of mitotic kinesin EG5 inhibitor monastrol.