Palladium(Ii)-Mediated Nucleophilic Cyanation Of 4-Substituted Quinoline 1-Oxide In The Presence Of Trimethylsilyl Cyanide And An Oxidant

摘要

Reaction of 4-substituted (electron-releasing group) quinoline 1-oxides (1) with trimethylsilyl cyanide in the presence of palladium(II) acetate and DDQ gave 2-cyano-4-substituted quinoline 1-oxides (2) in THF in moderate yields. It was reasoned that this reaction proceeds through palladium-catalyzed dehydrosilylation.