REACTIONS OF ALKYLATION OF BIOLOGICALLY INTERESTING TRIAZOLO[4,5-g]QUINOLINES AND TRIAZOLO[4,5-g]QUINOLINE-1- OXIDES WITH ELECTROPHILIC REAGENTS

摘要

With the aim to improve the biological activities discovered for compounds containing the triazolo[4,5-g]quinoline nucleus, we describe the chemical behaviour of 4-chlorotriazolo[4,5-g]quinolines (1a,b) and some its triazolo-N1-oxide derivatives (1c-e and II) with electrophilic reagents in order to optimize the synthetic pathways for obtaining both mixtures of N_(1,2,3)-alkyl isomers and selectively N1-O-alkyl derivatives.