New system of peptide synthesis was described.The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps,the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis,which was consisted of 3 steps of the deprotection,the activation and the condensation.Moreover,the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.
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