DOMINO-HYDROFORMYLATION-ALLYLBORATION-HYDROFORMYLATION FOR THE SYNTHESIS OF TRANS-2-ALKYLPIPERIDIN-3-OLS

摘要

Hydroformylation of an N-allyl-#gamma#-amidoallylboronate (7d) generates a formyl functio which allows intramolecular allylboration to proceed to give a vinylpiperidinol (11).The latter is again hydroformylated under the reaction conditions to furnish an oxa-aza-decalin ring system (12).