SYNTHESIS OF l,2,3,4,5,6,7,10-OCTAHYDRO-l,5-IMINO-7,10-DIOXO-3-BENZAZOCINE-4-CARBONITRILE DERIVATIVE AND EVALUATION OF ANTITUMOR ACTIVITY RELATED TO SAFRAMYCIN AND RENIERAMYCINISOQUINOLINEQUINONES

摘要

3-Benzyl-1,2,3,4,5,6,7,10-octahydro-9-methoxy-8,11 -dimethyl-7,10-dioxo-l,5-imino-3-benzazocine-4-carbonitrile (4) as a simple model of saframycin A and renieramycin M is prepared and its cytotoxicity tested against three human cancer cell lines.