Formal synthesis of anisomycin

摘要

A straightforward formal synthesis of anisomycin has been established starting from trans-4-hydroxyproline. The antibiotic anisomycin was first isolated from the fermentation broths of Streptomyces griselous and Streptomyces rosedochromogenes by Sobin and Tanner at Pfizer, Inc in 1954.