MULTICOMPONENT CYCLOCONDENSATIONS OF beta-KETOSULFONES WITH ALDEHYDES AND AMINOAZOLE BUILDING BLOCKS

摘要

The multicomponent reaction of methylsulfonylacetone (or a-methylsulfonylacetophenone) with aromatic aldehydes and aminoazoles (or urea) under microwave irradiation to yield 5,8-dihydroimidazolo[l,2-a]pyrimidines and 4,7-dihydro[l,2,4]triazolo[l,5-a]pyrimidines was studied. The influence of the type of aminoazole building block on the reactivity was established. In addition, an unusual reaction pathway for the Biginelli-type condensation of methylsulfonylacetone with aldehydes and urea leading to non-classical Hantzsch-type dihydropyridines was found.