SYNTHESIS OF AZA-ANALOG OF N-METHYLATED ACYCLOFORMYCIN A

摘要

Starting from 3-methyl-5-memylsulfanyl-1H-pyrazolo[4,3-e][l,2,4]-triazine (1) by reaction with methyl iodide,subsequent oxidation,ipso-substitution with hydrazine and reaction with yellow mercury (II) oxide l,3-dimethyl-1H-pyrazolo[4,3-e][l,2,4]triazine (14) is prepared.Further radical bromination and treatment with ethylene glycol in the presence of potassium carbonate afforded 3-(2-hydroxy-ethoxymethyl)-1-methyl-1H-pyrazolo[4,3-e]-[l,2,4]triazine (16) as aza-analog of N-methylated acycloformycin A.