Synthesis of new potential HIV-1integrase inhibitors

摘要

A synthesis of some l,2-(hetero)arylsubstituted ethanone and 1,3-(hetero)arylsubstituted 3-hydroxypropenone derivatives,designed as potential HIV-1 integrase inhibitors,is reported.The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields.All compounds prepared were tested to explore their potential anti-HIV activity.