Synthesis of 3-methylenepyrrolidines by palladium-catalyzed [3+2] cycloaddition of alkylidene-cyclopropanes with imines

摘要

Alkylidenecyclopropanes react with N-tosylimines in toluene in the presence of a catalytic amount of Pd(PPh_3)_4 and triphenylphosphine oxide to afford the corresponding [3+2] cycloaddition products,pyrrolidine derivatives,in good to excellent yields.