SYNTHETIC STUDIES ON GLYCOSPHINGOLIPIDS FROM PROTOSTOMIA PHYLA: SYNTHESIS OF GLYCOSPHINGOLIPID FROM THE MARINE SPONGE SPHECIOSPONGIA VESPARIA AND ITS ANALOGUE

摘要

Stereocontrolled syntheses of a neutral glycosphingolipid found from a marine sponge Spheciospongia vesparia and its analogue have been accomplished. Disaccharide glycosphingolipids, β-D-Arap-(1→6)-β-D-Glcp-(1<->1)-Cer (1) and α-D-Arap-(1→6)-β-D-Glcp-(l<->1)-Cer (2), were synthesized from suitable monosaccharide donors and an acceptor by stepwise synthesis.