New synthesis of model dihydroazepine-fused indolo [2,3-c] quinolines

摘要

A synthetic route involving double Pictet-Spengler condensation at the indolic C-2 and C-4 positions of a 3-diaminophenylindole (8) is described leading to a novel dihydroazepine-fused indoloquinoline system. MS and NMR spectral data are in accordance with the assigned pentacyclic structures namely, 7,8-dihydro-1,12-iminobenzo[c] pyrido [4,3,2-ef] [1] benzazepines (9a,b), as confirmed by X-Ray measurements.