Toward the assignment of liposidomycin stereochemistry: synthesis of 1,4-diazepan-3-one analogues by reductive amination approach

摘要

Toward the assignment of liposidomycin stereochemistry, a stereocontrolled synthesis of the liposidomycin diazepanone ring system and two precursors, has been achieved. The NMR coupling constants of a 5-phenyl model compound closely related to the liposidomycin diazepanone degradation product.