Immediate drug withdrawal and specialized treatment are essential in managing patients with toxic epidermal necrolysis

摘要

Toxic epidermal necrolysis (TEN), also known as LyelPs syndrome, is an unpredictable and potentially life-threatening adverse reaction to drugs.It involves extensive epidermal sloughing of the skin and erosive ulcerations of mucosal surfaces.Any external shearing force leads to separation of large sections of the epidermis from the dermis, and patients with TEN are considered to have acute skin failure. In addition, patients often develop mucositis of the mouth and genital area, inflammation of internal mucosal surfaces (e.g. gastrointestinal and respiratory tracts), and conditions affecting the eyes (e.g. conjunctivitis and corneal erosions; early involvement of the eye is seen in most patients).