Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts

Stiksrud Birgitte; Lorvik Kristina Berg; Kvale Dag; Mollnes Tom Eirik; Ueland Per Magne; Troseid Marius; Tasken Kjetil; Dyrhol-Riise Anne M.

首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts

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Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts

机译：血浆IP-10在免疫性非应答者中增加，并与激活的调节性T细胞和持续的低CD4计数相关

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Objective: To explore immune mechanisms and identify biomarkers associated with an inadequate immune recovery in patients with HIV with efficient antiretroviral therapy.

机译：目的：探讨通过有效抗逆转录病毒疗法治疗艾滋病毒患者的免疫机制并鉴定与免疫恢复不足有关的生物标志物。

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来源
《JAIDS: Journal of acquired immune deficiency syndromes》 |2016年第2期|共11页
作者
Stiksrud Birgitte; Lorvik Kristina Berg; Kvale Dag; Mollnes Tom Eirik; Ueland Per Magne; Troseid Marius; Tasken Kjetil; Dyrhol-Riise Anne M.;
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原文格式 PDF
正文语种 eng
中图分类传染病;
关键词
HIV; immunological nonresponders; IP-10; CXCL-10; Tregs; T-cell activation;

机译：HIV;免疫无反应者;IP-10;CXCL-10;Tregs;T细胞活化;

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1. Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts [J] . Stiksrud Birgitte, Lorvik Kristina Berg, Kvale Dag, JAIDS: Journal of acquired immune deficiency syndromes . 2016,第2期

机译：血浆IP-10在免疫性非应答者中增加，并与激活的调节性T细胞和持续的低CD4计数相关
2. Suppressive activity of regulatory T cells correlates with high CD4(+) T-cell counts and low T-cell activation during chronic simian immunodeficiency virus infection. [J] . Karlsson I, Malleret B, Brochard P, AIDS . 2011,第5期

机译：在慢性猿猴免疫缺陷病毒感染期间，调节性T细胞的抑制活性与高CD4（+）T细胞计数和低T细胞活化相关。
3. Increased Levels of STAT1 Protein in Blood CD4 T Cells from Systemic Lupus Erythematosus Patients Are Associated with Perturbed Homeostasis of Activated CD45RA(-)FOXP3(hi) Regulatory Subset and Follow-Up Disease Severity [J] . Goropevsek Ales, Gorenjak Maksimiljan, Gradisnik Suzana, Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2017,第6期

机译：来自全身狼疮红斑狼疮患者的血液CD4 T细胞中的STAT1蛋白水平增加与激活的CD45ra（ - ）Foxp3（HI）调节子集和随访疾病严重程度有关的扰动稳态
4. Development and function of IL-10-secreting regulatory T cells: Comparison with naturally occurring CD4~+CD25~+ regulatory T cells [C] . Anne OGarra Uehara Memorial Foundation Symposium on the Innate Immune System . 2005

机译：IL-10分泌监管T细胞的开发和功能：与天然存在的CD4〜+ CD25〜+调节性T细胞的比较
5. Using integrins to fine tune CD4+ T cell responses: How the integrin regulatory proteins calpain, PIPKIgamma'90, talin and focal adhesion kinase work together to regulate CD4+ T cell activation. [D] . Wernimont, Sarah A. 2011

机译：使用整合素来微调CD4 + T细胞反应：整合素调节蛋白calpain，PIPKIgamma'90，talin和黏着斑激酶如何协同作用来调节CD4 + T细胞活化。
6. Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery [O] . Birgitte Stiksrud, Hans C.D. Aass, Kristina B. Lorvik, -1

机译：HIV免疫无反应者中激活的树突状细胞和单核细胞：HIV诱导的干扰素诱导蛋白10与未来CD4 +回收率低相关
7. Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenotypes [O] . Wendy C. Brown, Joshua E. Turse, Paulraj K. Lawrence, 2015

机译：在胰岛素marginale感染后免疫诱导的特异性表位特异性CD4 T细胞反应需要在病原体上存在T细胞表位，并且与表达已知的调节细胞表型的淋巴细胞增加无关
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts

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