Inflammatory Twins from PI3K Gang Brought to Justice?

摘要

In 2007, Rommel et al. suggested that PI3Kd and PI3Kg were partners in crime in inflammation—working in concert and terrorizing our immune systems like cellular versions of Monty Python’s London gangsters, the cruel-but-fair Piranha Brothers (http://www.ethelthefrog.com/ ?tag=youtube). Williams et al. (2010) describe the compound SW14, their version of the determined Superintendent Harry ‘‘Snapper’’ Organs, single-handedly bringing down these kinase twins, compiling a broad dossier of evidence against them, and foreshadowing an exciting approach to treating inflammatory and immunological diseases.