Development of Nanostructured Phosphorite: Study of the Safety of Application

摘要

A nanostructured mineral food supplement with a particle size of 60.0—120.0 nm was manufactured from phosphorite by ultrasonic dispersion. It was found that intragastric administration of nanostruc-tures phosphorite to mice is relatively safe: clinical signs of intoxication appeared after a single administration of the preparation only at a dose of 90 mg/kg; a dose of 150 mg/kg caused death of 8% of mice, in which injuries of organs of the gastrointestinal tract were observed. When the preparation was administered subcutane-ously, intramuscularly, or intraperitoneally, small phosphorite conglomerates and inflammation of the surrounding tissues and organs were observed at the injection site. Death of 25% of animals was observed in the group of micewhich received intraperitoneal injections of nanophosphorite at a dose of 200 mg/kg.