Synthesis of New Nitroxyalkylamides as Potential Prototypes of Hybrid Nonsteroidal Anti-Inflammatory Drugs Containing NO-Donating Fragment

摘要

Nonsteroidal anti-inflammatory drugs (NSAIDs) (Aspirin, Indomethacin, Naproxen, Ibuprofen, and others) are used for many years as antipyretic and antiinflammatory agents. Moreover, Aspirin is used for the treatment of ischemia in patients with acute cardiac insufficiency and as a prophylactic for cardiovascular diseases [1]. However, the long-term use of these pharmaceuticals increases the risk of gastrointestinal disorders [2, 3]. The pharmacological properties and side effects of Aspirin and other NSAIDs arise immediately from the mechanism of their action, the inhibition of cyclooxygenases (COX-1 and COX-2), key enzymes in the synthesis of prostaglandins and thromboxanes [4].