首页> 外文期刊>Developmental and Comparative Immunology: Ontogeny, Phylogeny, Aging: The Official Journal of the International Society of Developmental and Comparative Immunology >Recognition of infectious non-self and activation of immune responses by peptidoglycan recognition protein (PGRP)-family members in Drosophila [Review]
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Recognition of infectious non-self and activation of immune responses by peptidoglycan recognition protein (PGRP)-family members in Drosophila [Review]

机译:果蝇中肽聚糖识别蛋白(PGRP)家族成员对传染性非自身的识别和免疫应答的激活[综述]

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Activation of the innate immune response involves recognition of the infectious non-self and subsequent activation of cellular and Immoral reactions. Insect Immoral reactions depend on primary and secondary responses. The primary response is mediated by the activation of cascades of constitutive proteins present in the hemolymph, such as the prophenoloxidase (proPO) cascade. The secondary response requires transcriptional activation of defense proteins, such as the induction of antimicrobial peptides. Drosophila possess specific mechanisms to discriminate between microbes and respond to infection by inducing the appropriate reactions. In innate immunity, pathogen-associated molecular patterns are recognized. The mechanisms for microbial recognition in Drosophila, however, are largely unknown. Recent data suggest that, in insect immunity, diverse peptidoglycan recognition protein members are involved in distinguishing between invading bacteria and activation of appropriate immune reactions. (C) 2003 Elsevier Ltd. All rights reserved. [References: 33]
机译:先天免疫反应的激活涉及对传染性非自身的识别以及随后的细胞和不体反应的激活。昆虫不育反应取决于主要和次要反应。主要反应是由血淋巴中存在的组成性蛋白(如酚氧化酶原(proPO)级联反应)的级联反应介导的。次要反应需要防御蛋白的转录激活,例如诱导抗菌肽。果蝇具有特定的机制来区分微生物并通过诱导适当的反应对感染作出反应。在先天免疫中,识别与病原体相关的分子模式。然而,果蝇中微生物识别的机制尚不清楚。最新数据表明,在昆虫免疫中,多种肽聚糖识别蛋白成员参与了入侵细菌的区分和适当免疫反应的激活。 (C)2003 Elsevier Ltd.保留所有权利。 [参考:33]

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