Does Type 2 diabetes increase the risk of developing cancer?

摘要

Over the past 30 years, a plethora of epi-demiologic studies have demonstrated a marked and consistent association between Type 2 diabetes (T2D) and the overall risk for cancer (and its mortality) in various populations [1-4]. However, it was also demonstrated that the strength of this association depended on the cancer site [13]. Indeed, the incidence of hepato-cellular and pancreatic cancers is doubled in patients presenting with T2D [1,3]. Endometrial cancer risk is also doubled in women with T2D [1,3], while risk of postmenopausal (but not premenopausal) breast, colorectal, kidney, biliary tract and bladder cancers, non-Hodgkin's lym-phoma, leukemia, and myeloma is 'only' 20-50% higher in patients presenting with T2D [1,3,5]. Notably, the risk of prostate cancer, by contrast, is approximately 15% lower in men with T2D [1,3].