A Prospective Study of Obesity and Risk of Coronary Heart Disease Among Diabetic Women.

摘要

OBJECTIVE-To examine the relationship of obesity, measured as BMI, and weight change to incidence of coronary heart disease (CHD) among women with diabetes. RESEARCH DESIGN AND METHODS-We followed 5,897 women with type 2 diabetes in the Nurses' Health Study for /=35.0 kg/m(2)) were 1.0, 1.58, 1.85, 1.95, 2.80, and 3.21, respectively (P for trend <0.001). Increasing BMI values from age 18 years to 1976, before diagnosis of diabetes, were also positively associated with risk of CHD. Weight gain before the diagnosis of diabetes was related to increased risk of CHD. In contrast, weight change after diagnosis of diabetes was not associated with risk of CHD. CONCLUSIONS-These findings provide strong evidence that obesity and weight gain before diagnosis of diabetes are associated with future risk of CHD among women with type 2 diabetes.