Granuloma faciale (GF) is an uncommon cutaneous disease which presents most often in middle-aged patients. Although its etiology is still unclear, many reports suggest that GF is a local form of cutaneous vasculitis. Many facts suggest that GF and erythema elevatum diutinum may be produced by a similar or the same pathogenic mechanism. For example, both are chronic localized forms of cutaneous leukocytoclastic vasculitis that result in patterned fibrosis. However, erythema elevatum diutinum often occurs in systemically ill patients as bilaterally symmetrical plaques, papules or nodules over the dorsa of joints, and GF usually appears as one or a few plaques on the face. In addition, eo-sinophils and plasma cells are prominent in GF, whereas neutro-phils are plentiful in erythema elevatum diutinum [1]. GF is often quite resistant to therapy [2-6]. Topical calcineurin inhibitors may represent a useful alternative to topical corticosteroids for the treatment of a number of other inflammatory skin diseases different from atopic dermatitis [7],
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