Sodium dehydroacetate is a preservative used in topical products such as cosmetics and creams for ulcer treatment. Generally known as a well-tolerated molecule with antimicrobial features, broad spectrum with good stability and non-volatility,1 it has been recently reported as a possible culprit allergen of allergic contact dermatitis (ACD).A 42-year-old nonatopic woman presented to our attention for the onset of eczematous lesions localized on her legs, mainly surrounding malleolar ulcers. History revealed that she had recurrent ulcers due to deep vein thrombosis associated with factor V Leiden and that, for this reason, she had been using various topical wound healing product. In particular, during the last month, she used a hyaluronic acid-based cream (Ialuset cream; Genevrier, Antibes, France) with a daily application. We performed patch test with the baseline S.I.D.A.P.A. (Italian Society of Allergological, Occupational and Environmental Dermatology) standard series (Euromed-ical?, Calolziocorte, LC, Italy) and with all the topical drugs she applied on her ulcers during the last year.
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