Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

Allen OR; Gott AL; Hartley JA; Hartley JM; Knox RJ; McGowan PC

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Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

机译：功能化的环戊二烯基钛化合物可作为潜在的抗癌药

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摘要

A number of new ionic titanocene compounds have been isolated and characterised, which exhibit excellent cytotoxicity against different human tumour cell lines including a defined cisplatin resistant cell line. A range of biological assays have been carried out to determine levels of cytotoxicity and levels of DNA interstrand crosslinking.

机译：已经分离和表征了许多新的离子钛茂化合物，它们对包括定义的顺铂耐药细胞系在内的不同人类肿瘤细胞系表现出优异的细胞毒性。已经进行了一系列生物学测定以确定细胞毒性水平和DNA链间交联水平。

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《Dalton transactions: An international journal of inorganic chemistry 》 |2007年第43期| 共9页
作者
Allen OR; Gott AL; Hartley JA; Hartley JM; Knox RJ; McGowan PC;
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正文语种 eng
中图分类无机化学 ;
关键词
TITANOCENE DICHLORIDE DERIVATIVES; COLONY-FORMING-UNITS; SUBSTITUTED TITANOCENES; CONFORMATIONAL-ANALYSIS; SATURATED HETEROCYCLES; ANTIPROLIFERATIVE ACTIVITY; ORGANOMETALLIC COMPOUNDS; CYTOTOXIC PROPERTIES; ANTITUMOR-ACTIVITY; TUMOR;

机译：钛茂新二氯衍生物;菌落形成单位;取代的钛烯;构象分析;饱和杂环;抗腐蚀活性;有机化合物;细胞毒性;抗肿瘤活性;

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1. Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs [J] . Allen OR, Gott AL, Hartley JA, Dalton transactions: An international journal of inorganic chemistry . 2007 ,第43期

机译：功能化的环戊二烯基钛化合物可作为潜在的抗癌药
2. Methyl-cyclopentadienyl Ruthenium Compounds with 2,2′-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential [J] . Leonor C?rte-Real, Ricardo G. Teixeira, Patrícia Gírio, Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2018 ,第8期

机译：甲基 - 环戊二烯基钌化合物与2,2'-硼啶衍生物显示出强烈的抗癌活性和多药耐药潜力
3. Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents [J] . de la Cueva-Alique Isabel, Munoz-Moreno Laura, Benabdelouahab Yosra, Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2016 ,第Null期

机译：新型对映体纯的环戊二烯基Ti（IV）肟酸酯化合物作为潜在的抗癌药
4. Nano_doped Rare Earth Compounds for Application of Anticancer Drugs [C] . Guilin Lu, ShaoHong Wang, HaiYuan Xie, International conference on opto-electronics engineering and information science . 2011

机译：纳米掺杂稀土化合物在抗癌药物中的应用
5. High-resolution NMR spectroscopic analysis of anticancer drugs, DNA and their interactions: 1. Platinum anticancer compounds - DNA interactions. 2. Anthracycline drugs - DNA interactions and modified DNA. [D] . Yang, Danzhou. 1996

机译：抗癌药物，DNA及其相互作用的高分辨率NMR光谱分析：1.铂类抗癌化合物-DNA相互作用。 2.蒽环类药物-DNA相互作用和修饰的DNA。
6. Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents [O] . Isabel de la Cueva-Alique, Laura Muñoz-Moreno, Yosra Benabdelouahab, -1

机译：新型对映体纯的环戊二烯基Ti（IV）肟酸酯化合物作为潜在的抗癌药
7. Methyl-cyclopentadienyl Ruthenium Compounds with 2,2′-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential [O] . Leonor Côrte-Real, Ricardo G. Teixeira, Patrícia Gírio, 2018

机译：甲基 - 环戊二烯基钌化合物与2,2'-硼啶衍生物显示出强烈的抗癌活性和多药耐药潜力

Functionalised cyclopentadienyl titanium compounds as potential anticancer drugs

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