Immunological Basis of Food Allergy (IgE-Mediated, Non-lgE-Mediated, and Tolerance)

摘要

Food allergy includes a number of diseases that present with adverse immunological reactions to foods and can be IgE-mediated, non-lgE-mediated, or a combination of both mechanisms. IgE-mediated food allergy involves immediate hypersensitivity through the action of mast cells, whereas non-lgE-mediated food allergy is most commonly cell-mediated. These food allergies are thought to occur as a result of a breakdown in oral tolerance and, more specifically, from an aberrant regulatory T-cell response. Ongoing studies of experimental treatments for food allergy strive to induce oral tolerance and to teach us more about the pathogenesis of food allergy.