Study of the Catalytic Activity of Zr(HPO_4)_2 in the Synthesis of Hexahydroquinoline Derivatives under Solvent-free Conditions

摘要

2-Amino-7,7-dimethyl-5-oxo-1,4-diaryl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile derivatives were synthesized by the one-pot four-component reaction of aromatic aldehydes, malononitrile, dimedone and arylamines in the presence of Zr(HPO_4)_2·H_2O (a-ZrP) as an effective and recyclable solid acid catalyst, in high yields.