Nitroimidazoles part 7. Synthesis and Anti-HIV activity of new 4-Nitroimidazole derivatives

摘要

Reverse transcriptase enzyme(RT)is an attractive target for the development of new drugs useful in AIDS therapy and HIV non-nucleoside reverse transcriptase inhibitors(NNRTIs), and offers the possibility of generating structures of increased potency. On this basis, a series of 4-oxo-3-phenyl-2-(phenylimino)thiazolidin-5-ylidene, 3-hydroxypropyl, 3-azidopropyl, and 3-aminopropyl derivatives of 1-benzyl-2-ethyl-4-nitroimidazoles 6-8, as well as the substituted 1, 2, 3-triazolo analogs 12-14, the diazepam 15 and carboxamide derivatives 16 and 17 were synthesized. All compounds have been evaluated for their anti-HIV activity.