A distinctive translocation carcinoma of the kidney; 'rosette forming,' t(6;11), HMB45-positive renal tumor: A histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases

摘要

We have read the interesting article of Petersson et al [1] in which they exhaustively study 4 cases of "rosette-forming" t(6;ll), HMB45-positive renal tumors, a variant of traslocation-associated carcinoma of kidney. On histologic examination in 1 of the cases, the authors describe "branching and tubular structures, rimmed by one row of neoplastic cells with granular cytoplasms having the nuclei aligned on the basement membrane, giving these structures a resemblance to glandular epithelium (Figures 3,4,5). In serial cut sections, it was apparent that these branching and tubular structures opened into areas with pseudorosettes (Figure 7)."