Angiotensin II type 1 receptor gene regulation: transcriptional and posttranscriptional mechanisms.

摘要

Angiotensin II (Ang II), the major bioactive peptide of the renin-angiotensin system, was originally described as a potent vasoconstrictor. It is now recognized as a multifunctional hormone influencing many cellular processes, including cell growth, apoptosis, migration, inflammation, and fibrosis.Under pathological conditions, the vasoconstrictor, mitogenic, proinflammatory, and profibrotic actions of Ang EE contribute to altered vascular tone, structural remodeling, and endothelial dysfunction. Thus, Ang II plays a key role in the pathogenesis of cardiovascular diseases.