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Glycoconjugate vaccine strategies for protection against invasive Salmonella infections

机译:糖缀合物疫苗策略可预防沙门氏菌感染

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Salmonella enterica serovars Typhi and Paratyphi A and B and certain non-typhoidal Salmonella enterica (NTS) serovars are important causes of invasive Salmonella disease worldwide. NTS serovars Typhimurium and Enteritidis typically cause gastroenteritis in healthy children and adults in industrialized countries but in certain hosts (e.g., young infants, the elderly, immuno compromised individuals) they also cause invasive infections. These two serovars also cause invasive disease in infants and young children in sub-Saharan Africa. Whereas Salmonella surface polysaccharides are poor immunogens in animal models and do not generate immunologic memory, conjugation with carrier proteins overcomes these limitations.
机译:伤寒沙门氏菌伤寒沙门氏菌和副伤寒A和B以及某些非伤寒性肠炎沙门氏菌(NTS)沙门氏菌是全世界侵袭性沙门氏菌病的重要原因。 NTS鼠伤寒和肠炎沙门氏菌通常在工业化国家的健康儿童和成人中引起肠胃炎,但在某些宿主(例如,婴儿,老年人,免疫功能低下的人)中,它们也引起侵袭性感染。这两种血清型还导致撒哈拉以南非洲的婴幼儿侵袭性疾病。沙门氏菌表面多糖在动物模型中是较弱的免疫原,不会产生免疫记忆,而与载体蛋白的结合克服了这些限制。

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